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Intermediate Filament Keratins in the Exocrine Pancreas

Book Chapter

Alam, C., Baghestani, S., & Toivola, D. M. (2021)

Intermediate Filament Keratins in the Exocrine Pancreas. In J. A. Williams, & F. S. Gorelick (Eds.), The Pancreas: Biology and Physiology (72-84). Michigan Publishing

Intermediate filament keratins are cytoskeletal components in epithelial tissues, including the exocrine pancreas. Keratin (K) intermediate filaments are highly conserved prot...

Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes

Journal Article

Alam, C. M., Baghestani, S., Pajari, A., Omary, M. B., & Toivola, D. M. (2021)

Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes. International Journal of Molecular Sciences, 22(15), Article 7784. https://doi.org/10.3390/ijms22157784

Keratin (K) 7 is an intermediate filament protein expressed in ducts and glands of simple epithelial organs and in urothelial tissues. In the pancreas, K7 is expressed in exoc...

Keratin intermediate filaments in the colon: guardians of epithelial homeostasis

Journal Article

Polari, L., Alam, C. M., Nyström, J. H., Heikkilä, T., Tayyab, M., Baghestani, S., & Toivola, D. M. (2020)

Keratin intermediate filaments in the colon: guardians of epithelial homeostasis. International Journal of Biochemistry and Cell Biology, 129, Article 105878. https://doi.org/10.1016/j.biocel.2020.105878

Keratin intermediate filament proteins are major cytoskeletal components of the mammalian simple layered columnar epithelium in the gastrointestinal tract. Human colon crypt e...

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity

Journal Article

Siddiqui, F. A., Alam, C., Ora, M., Sabt, A., Manoharan, G. B., Bindu, L., …Abankwa, D. (2020)

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity. ACS Omega, 5(1), 832-842. https://doi.org/10.1021/acsomega.9b03639

The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D ...

Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes

Journal Article

Alam, C., Silvander, J., Helenius, T., & Toivola, D. (2018)

Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes. Acta physiologica, 224(2), Article e13085. https://doi.org/10.1111/apha.13085

Aim Diabetes is a result of an interplay between genetic, environmental and lifestyle factors. Keratin intermediate filaments are stress proteins in epithelial cells, and kera...

Keratins regulate β‐cell mitochondrial morphology, motility, and homeostasis

Journal Article

Silvander, J. S. G., Kvarnström, S. M., Kumari‐Ilieva, A., Shrestha, A., Alam, C. M., & Toivola, D. M. (2017)

Keratins regulate β‐cell mitochondrial morphology, motility, and homeostasis. FASEB Journal, 31(10), 4578-4587. https://doi.org/10.1096/fj.201700095r

Loss of the epithelial intermediate filament protein keratin 8 (K8) in murine β cells leads to irregular insulin vesicles and decreased insulin levels. Because mitochondria ar...

Diatom-inspired skeletonisation of insulin - Mechanistic insights into crystallisation and extracellular bioactivity

Journal Article

Véliz, D. S., Alam, C., Nietzel, T., Wyborski, R., Rivero-Müller, A., & Alam, P. (2015)

Diatom-inspired skeletonisation of insulin - Mechanistic insights into crystallisation and extracellular bioactivity. Colloids and Surfaces B: Biointerfaces, 133, 140-147. https://doi.org/10.1016/j.colsurfb.2015.05.047

In this paper, we encage insulin within calcium carbonate by means of a biomineralisation process. We find that both dogbone and crossbone morphologies develop during the crys...

The amount of keratins matters for stress protection of the colonic epithelium

Journal Article

Asghar, M. N., Silvander, J. S. G., Helenius, T. O., Lähdeniemi, I. A. K., Alam, C., Fortelius, L. E., …Toivola, D. M. (2015)

The amount of keratins matters for stress protection of the colonic epithelium. PLOS ONE, 10(5), Article e0127436. https://doi.org/10.1371/journal.pone.0127436

Keratins (K) are important for epithelial stress protection as evidenced by keratin mutations predisposing to human liver diseases and possibly inflammatory bowel diseases. A ...

Peritoneal cavity is a route for gut-derived microbial signals to promote autoimmunity in non-obese diabetic mice

Journal Article

Emani, R., Alam, C., Pekkala, S., Zafar, S., Emani, M., & Hänninen, A. (2015)

Peritoneal cavity is a route for gut-derived microbial signals to promote autoimmunity in non-obese diabetic mice. Scandinavian Journal of Immunology, 81(2), 102-109. https://doi.org/10.1111/sji.12253

Macrophages play a crucial role in innate immune reactions, and peritoneal macrophages (PMs) guard the sterility of this compartment mainly against microbial threat from the g...

Keratins in health and disease

Journal Article

Toivola, D. M., Boor, P., Alam, C., & Strnad, P. (2015)

Keratins in health and disease. Current Opinion in Cell Biology, 32, 73-81. https://doi.org/10.1016/j.ceb.2014.12.008

The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and their inherited and spontaneous mutations give rise to keratinopathies. For example,...